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High-dose IV glutathione can lead to serious side effects, including kidney stress or allergic reactions

As well as supressing COX-2 synthesis, betanidin, extracted from beetroot, dose dependently inhibited (to 9% of control activity), lipoxygenase (LOX), a catalytic enzyme vital for the synthesis of pro-inflammatory leukotriene molecules [70]

Fructose-6-phosphate can also be used by the phosphofructokinases (Pfkl, m, p) into glycolysis or diverted toward the hexosamine biosynthesis pathway

Therefore, supplementing with high-quality glutathione can be an effective strategy to boost our internal antioxidant defenses